Uniform Particle Size Distribution Research Articles

The Preparation and Performance of Epoxy/Acetylene Carbon Black Wave-Absorbing Foam.

The epoxy foam material filled with an absorbing agent effectively absorbs electromagnetic waves. In this study, epoxy resin was used as the matrix, and acetylene carbon black was used as the magnetic absorbing agent to prepare an absorbing foam material (epoxy/CB). The microstructure of acetylene carbon black (CB) and its distribution in epoxy resin, as well as the effects of pre-polymerization time and CB content on the foam structure, were systematically characterized. Additionally, two dispersion methods, the hot-melt in situ stirring dispersion method and the three-roll milling dispersion method, were studied for their effects on the foaming process and absorbing properties of epoxy/CB. The results showed that with the prolongation of pre-polymerization time, the pore size decreased from 1.02 mm to 0.4 mm, leading to a more uniform pore distribution. Compared to the hot-melt in situ stirring dispersion method, the three-roll milling dispersion method effectively improved the dispersion of CB in epoxy resin, reducing the aggregate size from 300-400 nm to 70-80 nm. The pore diameter also decreased from 0.453 mm to 0.311 mm, improving the uniformity of particle size distribution. However, the absorbing material prepared with the three-roll milling dispersion method exhibited unsatisfactory absorption performance, with values close to 0 dB at mid-low frequencies and around -1 dB at high frequencies. In contrast, the absorbing material prepared with the hot-melt in situ stirring dispersion method showed better absorption performance at high frequencies, reaching around -9 dB.

Fischer-Tropsch to olefin reaction over Fe-based catalysts: Effect of preparation method and synergistic effect of Mn and Zr promoters

BackgroundDirect production of light olefins (basic chemical raw materials in the industrials) from syngas using promoted catalysts demonstrates great potential, because of their upgraded performances. MethodsIn this study, a series of Fe-based catalysts promoted by Mn and Zr were prepared by hydrothermal and microemulsion methods and applied to the Fischer-Tropsch reaction. To optimize the catalysts, response surface methodology combined with the central composite design was applied to three independent parameters of the synthesis method, weight percent of Zr promoter (2th promoter) and reaction temperature. To clarify the relationship between the synthesis methods, the synergistic effect of Zr and Mn promoters, and catalyst performance, in detail, different characterization analyses were studied, including XRD, BET, SEM-EDS, FESEM, TEM, H2-TPR, and CO-TPR. Significant findingsAccording to developed statistical equations, it was revealed that the synthesis method is the most influential parameter on CO% and O/P ratio. The experimental results indicated that Zr and Mn promoters had a negative synergistic effect on the CO% and O/P, but a positive one on the heavy hydrocarbons selectivities. The characterization results demonstrated that hydrothermal prepared FeMn catalyst, due to having uniform particle size distribution, cubic morphology, and better reduction at low temperature had highest CO%.

Fluorescence Detection of Pb2+ in Environmental Water Using Biomass Carbon Quantum Dots Modified with Acetamide-Glycolic Acid Deep Eutectic Solvent.

In this study, a novel green fluorescent probe material, nitrogen-doped carbon quantum dots (N-CQDs), was prepared by a one-step hydrothermal synthesis method using walnut green skin as a carbon source and acetamide-glycolic acid deep eutectic solvent (AGADES) as a modifier. By covalent coupling, the amide chromophore in AGADES is designed to cover the surface of walnut green skin carbon quantum dots (W-CQDs), forming a fluorescence energy resonance effect and improving the fluorescence performance of the carbon quantum dots. The prepared N-CQDs have a uniform particle size distribution, and the fluorescence quantum efficiency has increased from 12.5% to 32.5%. Within the concentration range of 0.01~1000 μmol/L of Pb2+, the linear detection limit is 1.55 nmol/L, which can meet the trace detection of Pb2+ in the water environment, and the recycling rate reaches 97%. This method has been successfully applied to the fluorescence detection and reuse of Pb2+ in actual water bodies, providing new ideas and methods for the detection of heavy metal ions in environmental water.

Preparation and Mechanical Properties of Core-Shell PS&CeO2 Composite Abrasive Particles.

Core-shell composite abrasive particles are a topic of great interest in surface finishing. It is important to explore the preparation technology and performance parameters associated with them. In this paper, a core-shell composite abrasive particle made of polystyrene and cerium oxide (PS&CeO2, CSPC), which is rigid on the outside and flexible on the inside, is proposed. The microstructure, physical phase characteristics, and mechanical properties of the inner core and composite abrasive particles are investigated. PS microspheres and CSPC composite abrasive particles with different structural features were prepared through a series of experiments, morphological observations, and physical and chemical characterization experiments. Their microstructures and physical phase properties were investigated. The indentation load curves of the PS microspheres and CSPC composite abrasive samples were measured by using an atomic force microscope. The analysis focused on the effects of various dimensional and structural parameters on the modulus of elasticity of both PS microspheres and CSPC composite abrasive particles. The analysis shows that the experimentally prepared PS microspheres have good dispersion, a smooth surface, and a uniform particle size distribution. The prepared CSPC composite abrasive particles are regular spheres with rough, rice-like surfaces, low modulus of elasticity, and overall nonrigid and soft elastic properties. The results of this paper can provide a guide for the preparation technology, performance regulation, and application of polymer microspheres and core-shell composite abrasive particles in CMP.

Low-temperature synthesis and properties of high-purity boron nitride microspheres

Boron nitride (BN) has excellent high temperature resistance, thermal conductivity, strong insulation, and wave-transparent properties. Spherical BN is an essential filler in polymer matrix composites due to good particle mobility and high filler content. In this paper, we present a large-scale preparation for BN microspheres with uniform particle size distribution in the range of 1.0–2.8 μm via solvothermal method at low cost and high yield (∼90%), which is two orders of magnitude lower than the diameter of the spherical BN prepared by other methods. BN microspheres can achieve good crystallinity (>70%) and high purity (>99.9%) at 800 °C. The temperature resistance study showed that the BN microspheres could maintain the dense particle morphology at 1200 °C. In addition, the prepared BN microspheres have good dielectric and thermal conductivity properties (dielectric constant ∼3.4, dielectric loss ∼2.0 × 10−3, and thermal conductivity of 9.8 W m−1 K−1), which show great potential in the field of wave-transparent and thermal conductive composites. The synthesis process of BN microspheres proposed in this study provides a new idea for the preparation of ceramic micro or nano materials by polymer-derived ceramics.

Preferential formation of uniform spherical vaterite by harnessing vortex flows and integrated CO2 capture and mineralization

The production of solid calcium carbonate for reuse is a significant advance of integrated CO2 capture and mineralization using regenerable solvents. However, a crucial challenge with carbon mineralization is the lack of specificity in the formation of various calcium carbonate phases. One of the less explored but highly effective approaches to tune the morphology and crystal structure of specific carbonate phases involves tuning vortex flows. This approach is an alternative to harnessing chemical reagents that need to be regenerated for tuning the morphologies and crystalline structures to direct the formation of specific carbonate phases. In this study, the efficacy of harnessing homogeneous vortex flows in limiting the agglomeration of carbonate particles and directing the formation of metastable vaterite phases is discussed and contrasted with the influence of inhomogeneous conventional feed flow patterns on precipitated calcium carbonate (PCC). Herein, a Taylor-Couette Carbonate Conversion (TC3) reactor is harnessed to direct the formation of spherical vaterite particles with uniform particle size distribution preferentially over calcite and other phases. The formed vortex patterns inside TC3 reactor provide homogeneous reaction spaces conducive to PCC formation, ensuring uniform mixing throughout the process. By increasing the rotational strength and the residence time, higher purity carbonates with more uniform sizes are obtained. Furthermore, preferential vaterite formation is also observed in leachates obtained from alkaline industrial residues such as construction and demolition waste and steel slag. Thus, the proposed approach is effective in harnessing multiple waste streams such as CO2 emissions and alkaline industrial residues to produce calcium carbonate phases such as vaterite with structural and morphological specificity.

Preparation of soy protein isolate-naringin-chitosan protein gel: Synergistic effect of ohmic heating pre-treatment and chitosan addition

Soybean protein isolate (SPI)-Naringin (Nar) complex pre-aggregates were prepared by ohmic heating (OH) and protein gels were formed by adding chitosan (CS). The properties of the pre-aggregate, gel rheological properties, texture, and water holding capacity (WHC) were evaluated. For the properties of the SPI-Nar pre-aggregate, under an OH treatment of 6 V/cm, the α-helix and β-turn structures of the SPI-Nar pre-aggregate were found to be 17.72% and 15.30%, respectively, with a uniform particle size distribution. The surface hydrophobicity, total free sulfhydryl, and turbidity were measured to be 794, 6.54 μmol SH/g, and 0.364, respectively. Atomic force microscopy images showed an Rq value of 3.63 and a height of 14.5 nm. Regarding the properties of the SPI-Nar-CS protein gel, when the CS addition level was 3%, the gel (SPI-Nar-CS 3) exhibited the best rheological properties, with hardness, springiness, and cohesiveness values of 10.17 g, 0.79 mm, and 0.31, respectively. The WHC and LF-NMR analysis of the protein gel revealed that SPI-Nar-CS 3 exhibited a WHC of 90.67% and optimal LF-NMR imaging and apparent state. SEM images showed the best microstructure at this CS addition level. In addition, the synergistic mechanism between the OH treatment and CS addition in protein gel formation was discussed, providing a theoretical foundation for future applications in the food industry.

A Non-Disposable Electrochemical Sensor Based on Laser-Synthesized Pd/LIG Nanocomposite-Modified Screen-Printed Electrodes for the Detection of H2O2.

There have been many studies on the significant correlation between the hydrogen peroxide content of different tissues or cells in the human body and the risk of disease, so the preparation of biosensors for detecting hydrogen peroxide concentration has been a hot topic for researchers. In this paper, palladium nanoparticles (PdNPs) and laser-induced graphene (LIG) were prepared by liquid-phase pulsed laser ablation and laser-induced technology, respectively. The complexes were prepared by stirring and used for the modification of screen-printed electrodes to develop a non-enzymatic hydrogen peroxide biosensor that is low cost and mass preparable. The PdNPs prepared with anhydrous ethanol as a solvent have a uniform particle size distribution. The LIG prepared by laser direct writing has good electrical conductivity, and its loose porous structure provides more adsorption sites. The electrochemical properties of the modified electrode were characterized by cyclic voltammetry, chronoamperometry, and electrochemical impedance spectroscopy. Compared with bare screen-printed electrodes, the modified electrodes are more sensitive for the detection of hydrogen peroxide. The sensor has a linear response range of 5 µM-0.9 mM and 0.9 mM-5 mM. The limit of detection is 0.37 µM. The above conclusions indicate that the hydrogen peroxide electrochemical biosensor prepared in this paper has great advantages and potential in electrochemical catalysis.

Synthesis and characterization of alginate-polyacrylic acid/multiwalled carbon nanotubes composite with efficient removal for nigrosine dye

ABSTRACT The current study detailed the efficacy of a simply prepared alginate-polyacrylic acid/functionalized multiwalled carbon nanotubes (Alg-PAA/f-MWCNTs) composite for adsorption of nigrosine dye (acid black II) from aqueous environments. Firstly, preparation of the Alg-PAA/f-MWCNTs composite was achieved via gamma radiation-induced template polymerization of AA onto the Alg/f-MWCNTs surface. The maximum grafting efficiency (GE%) of AA onto the surface of Alg/f-MWCNTs was ~ 82% under the optimized conditions: (2.5 wt% Alg, 30 wt% AA, 0.5 wt% f-MWCNTs, 0.6 wt% N,N’-methylenebisacrylamide (NMBA), and irradiation dose ~ 20 kGy). The structural characteristics, thermal features as well as the morphological appearance of the Alg-PAA/f-MWCNTs composite were validated using different analyses including FTIR, TGA, DTA, XRD and SEM. Additionally, the composite exhibited uniform particle size distribution (~150.7 nm), point of zero charge at pH = 6.28, and negative Zeta potentials of a minimum at pH = 2. The adsorption batch experiments showed good adsorption capacity for the nigrosine dye from their aqueous media with adsorption efficiency up to 83% using the batch technique at pH = 2.0 for 420 min. The adsorption of nigrosine dye onto Alg-PAA/f-MWCNTs is favorable thermodynamically, obeying the Freundlich isotherm model and controlled by a chemisorption mechanism. Additionally, the composite showed a good regeneration ability up to five times with almost the same removal of ~80%. The results demonstrated that the Alg-PAA/f-MWCNTs composite could be a promising candidate for the removal of nigrosine dye from industrial aqueous environments.

Characterization of mechanochemical modification in SiC powder

In this study, SiC powder was prepared via a mechanochemical method utilizing high-energy ball milling. The SiC powder, subjected to varying milling durations, was analyzed using X-ray diffraction, Masterizer2000, and scanning electron microscopy. The results indicate that SiC powder achieves a uniform distribution of particle size after 5 min of ball milling, resulting in smaller particle diameters and a larger specific surface area. Concurrently, it exhibits high solid activity and enhanced purity. This suggests that a brief period of ball milling is sufficient to significantly improve the physical properties of SiC powder, which is crucial for applications requiring high material purity and reactive surface area.

Preparation, characterization and in vitro digestion of jujube polysaccharide microcapsules

The preparation of jujube polysaccharide microcapsules was investigated in this study. Microcapsule technology was employed to encapsulate jujube polysaccharides, effectively isolating them from external substances and facilitating their smooth passage through the intestinal tract. The objective was to control the release and prolong the release time of the polysaccharides. Additionally, we evaluated the characteristics of these microcapsules and their in vitro solubility and digestive behaviors. The findings demonstrated that the optimal preparation conditions, measured by the encapsulation efficiency, included a sodium alginate concentration of 4% (w/v), a core-to-wall ratio of 1:6, a calcium chloride concentration of 3% (w/v), and a chitosan concentration of 0.5% (w/v). The factors influencing the process ranked in the following order: core-to-wall ratio > sodium alginate concentration > chitosan concentration > CaCl2 concentration. The microcapsules produced under the optimal conditions exhibited a remarkable encapsulation efficiency of 97.29%. The characterization and analysis of the jujube polysaccharide microcapsules confirmed their successful encapsulation, uniform particle size distribution, and robust thermal stability. In addition, swelling and in vitro release trials demonstrated that the jujube polysaccharide microcapsules exhibit excellent swelling characteristics and consistent and prolonged release patterns. These distinct characteristics are anticipated to significantly impact functional food and medicine.

PREPARATION OF CITRONELLAL NANOCAPSULES AND STUDY OF ANTIBACTERIAL AND MOSQUITO REPELLENT PROPERTIES OF CITRONELLAL FUCTIONALIZED LYOCELL FIBER

The encapsulation of botanical compounds (such as citronellal) can be used to increase their efficiency and stability for functionalizing textile materials. In this study, the citronellal nanocapsules (CNC) with citronella oil as the core material and isophorone diisocyanate (IPDI) as the shell material were prepared and characterized. Factors, including core-to-shell ratio, single-phase ratios, emulsification time, as well as polymerization time and temperature, were investigated to determine the optimal process for the preparation of CNC. The average particle size of the prepared CNC was about several hundred nanometers, with uniform particle size distribution. Further, composite Lyocell fibers were prepared by the wet spinning process of co-blending CNC with Lyocell spinning stock. Evaluations were made of the biological activity of CNC towards mosquitoes, as well as E. coli and S. aureus, showing excellent mosquito repelling rate, of more than 90%, and an inhibition rate of 97.72% towards S. aureus.

Property Enhancement of Waste Printed Circuit Boards Powders Reinforced Polypropylene by In Situ Magnesium Hydroxide Impregnation from Waste Lye.

Using alkali pretreatment can effectively remove residual variable-valence metals from non-metallic powder (WPCBP) in waste printed circuit boards. However, substantial amounts of waste lye are generated, which causes secondary pollution. On this basis, this study innovatively utilized waste alkali lye to prepare nano-magnesium hydroxide. When the dispersant polyethylene glycol 6000 was used at a dosage of 3 wt.% of the theoretical yield of magnesium hydroxide, the synthesized nano-magnesium hydroxide exhibited well-defined crystallinity, good thermal stability and uniform particle size distribution, with a median diameter of 197 nm. Furthermore, the in situ method was selected to prepare WPCBP/Mg(OH)2 hybrid filler (MW) and the combustion behavior, thermal and mechanical properties of PP blends filled with MW were evaluated. The combustion behavior of the PP/MW blends increased with the increasing hybrid ratio of Mg(OH)2, and the MW hybrid filler reinforced PP blends showed better thermal and mechanical properties compared to the PP/WPCBP blends. Furthermore, the dynamic mechanical properties of the PP/MW blends were also increased due to the improved interfacial adhesion between the MW fillers and PP matrix. This method demonstrated high economic and environmental value, providing a new direction for the high value-added utilization of WPCBP.

Li1.3Al0.3Ti1.7(PO4)3 (LATP) solid electrolytes synthesized by microwave-assisted hydrothermal reactions for Li all-solid-state battery applications

Sub-micron LATP solid electrolytes have been prepared via a facile microwave-assisted hydrothermal method. The structure and ionic conductivity of LATP has been investigated as a function of hydrothermal synthesis temperature by powder X-ray diffraction (XRD), thermal analysis, scanning electron microscopy (SEM), and electrochemical impedance spectroscopy (EIS). The hydrothermal synthesis temperature is pivotal in controlling the uniformity of the LATP particle size distribution and the surface morphology of the electrolyte. Optimal LATP pellets prepared from powder synthesized at 180 °C exhibit an ionic conductivity of 1.4 × 10−4 S cm−1 at 298 K, while variable temperature measurements yielded activation energy of 0.253 eV for Li diffusion. These favorable values could reflect the uniform particle size distribution, high crystallinity and a relative density as high as 97 %. The optimum electrolyte material was applied in an NCM523/LATP/Graphite pouch cell, which demonstrated a stable capacity (≥ 92.5 % at a Coulombic efficiency of ∼100 %) for >400 cycles. The results indicate that LATP synthesized by microwave-assisted hydrothermal methods performs very effectively as a solid electrolyte and is a credible candidate for all-solid-state LIBs.

Preparation of unsaturated self-emulsifying polyester sizing agents for improving interfacial and mechanical properties of carbon fiber/vinyl ester resin composites

In order to promote the interfacial adhesion between carbon fiber and vinyl ester matrix, a series of unsaturated self-emulsifying anionic polyester sizing agents were designed. The results indicated that the sizing agents exhibited a uniform particle size distribution at the nanometer level and demonstrated favorable thermal stability below 200 °C. As the content of double bonds of sizing agents increases, the glass transition temperature also increases, and the moisture absorption of sized carbon fiber decreases. The carbon fiber surface becomes smoother after sizing. Moreover, the interlaminar shear strength and interfacial shear strength increased by 18.8 % and 43.4 %, respectively, compared to the commercial carbon fiber. This is mainly due to the unsaturated bonds in the sizing agent react with the free radicals on the surface of the carbon fiber, which enhance the interface bonding strength between the sizing agent and the surface of the carbon fiber and the vinyl ester matrix.

Li3V2(PO4)3 Cathode Material: Synthesis Method, High Lithium Diffusion Coefficient and Magnetic Inhomogeneity.

Li3V2(PO4)3 cathodes for Li-ion batteries (LIBs) were synthesized using a hydrothermal method with the subsequent annealing in an argon atmosphere to achieve optimal properties. The X-ray diffraction analysis confirmed the material's single-phase nature, while the scanning electron microscopy revealed a granular structure, indicating a uniform particle size distribution, beneficial for electrochemical performance. Magnetometry and electron spin resonance studies were conducted to investigate the magnetic properties, confirming the presence of the relatively low concentration and highly uniform distribution of tetravalent vanadium ions (V4+), which indicated low lithium deficiency values in the original structure and a high degree of magnetic homogeneity in the sample, an essential factor for consistent electrochemical behavior. For this pure phase Li3V2(PO4)3 sample, devoid of any impurities such as carbon or salts, extensive electrochemical property testing was performed. These tests resulted in the experimental discovery of a remarkably high lithium diffusion coefficient D = 1.07 × 10-10 cm2/s, indicating excellent ionic conductivity, and demonstrated impressive stability of the material with sustained performance over 1000 charge-discharge cycles. Additionally, relithiated Li3V2(PO4)3 (after multiple electrochemical cycling) samples were investigated using scanning electron microscopy, magnetometry and electron spin resonance methods to determine the extent of degradation. The combination of high lithium diffusion coefficients, a low degradation rate and remarkable cycling stability positions this Li3V2(PO4)3 material as a promising candidate for advanced energy storage applications.

Synthesis of Nano-aluminum Nitride powder at low temperature by Sol-gel method

In this paper, molecular-level mixed aluminum nitride has been prepared from aluminum sec-butyl alcohol, glucose, and urea by sol-gel processing. Then, the nano-aluminum nitride powder with uniform particle size distribution was obtained by carbothermal reduction nitridation reaction. The effects of different feed ratios, reaction temperatures, and holding times on the phase of AlN powder were systematically studied. The prepared nano-aluminum nitride powder has a uniform particle size and a near-spherical shape, and its grain size is approximately 20~30 nm. The preparation temperature in this method was significantly reduced from the same preparation method of aluminum nitride powder.

Dual-Targeting Macrophages and Hepatic Stellate Cells by Modified Albumin Nanoparticles for Liver Cirrhosis Treatment.

Hepatic cirrhosis has become a global public health concern with high mortality and currently lacks effective clinical treatment methods. Activation of hepatic stellate cells (HSCs) and the large number of macrophages infiltrating into the liver play a critical role in the development of liver cirrhosis. This study developed a novel modified nanoparticle system (SRF-CS-PSA NPs) in which Sorafenib (SRF) was encapsulated by palmitic acid-modified albumin (PSA) and further modified with chondroitin sulfate (CS). These modifications enabled the SRF-CS-PSA NPs to effectively target hepatic stellate cells (HSCs) and macrophages. SRF-CS-PSA NPs showed uniform particle size distribution of approximately 120 nm and high loading efficiency of up to 99.5% and can be taken up by HSCs and macrophages via CD44 and SR-A receptors, respectively. In a mouse model of liver cirrhosis, SRF-CS-PSA NPs demonstrated superior targeting and inhibition of HSCs and macrophages, effectively reversing the process of liver cirrhosis. Overall, our study demonstrates the potential of SRF-CS-PSA NPs as a targeted therapy for liver cirrhosis, with promising clinical applications.

Tauroursodeoxycholic acid liposome alleviates DSS-induced ulcerative colitis through restoring intestinal barrier and gut microbiota

Ulcerative colitis (UC) is a chronic and progressive inflammatory disease that damages the colonic mucosa and disrupts the intestinal epithelial barrier. The current clinical treatment for UC is mainly chemotherapy, which has the limited effectiveness and severe side effects. It mainly focuses on the treatment of inflammation while neglecting the repair of the intestinal mucosa and the restoration of the microbiota balance. Here, we aimed to address these challenges by using an amphipathic bile acid -tauroursodeoxycholic acid (TUDCA) to replace cholesterol (CHL) in conventional liposomes. We prepared TUDCA/Emodin liposomes by incorporating the hydrophobic drug emodin. The experimental results indicated that TUDCA/Emodin Lip had uniform particle size distribution, good stability, low cytotoxicity, and exhibited good mucus permeability and anti-inflammatory activity in in vitro experiments, and was able to protect cells from oxidative stress. After oral administration, TUDCA/Emodin Lip significantly alleviated the severity of UC. This was evidenced by increased colon length, decreased inflammation and reduced colonic endoplasmic reticulum stress (ERS). Furthermore, TUDCA/Emodin Lip maintained the normal levels of the tight junction proteins Claudin-1 and ZO-1, thereby restoring the integrity of the intestinal barrier. Importantly, TUDCA/Emodin Lip also promoted the ecological restoration of the gut microbiota, increased overall abundance and diversity. Taken together, TUDCA/Emodin Lip can fundamentally restore intestinal homeostasis, this work provides a new, efficient and easily transformable treatment for UC.

Effects of folate-chicory acid liposome on macrophage polarization and TLR4/NF-κB signaling pathway in ulcerative colitis mouse

BackgroundChichoric acid (CA) is a major active ingredient found in chicory and Echinacea. As a derivative of caffeic acid, it has various pharmacological effects. PurposeDue to the unclear etiology and disease mechanisms, effective treatment methods for ulcerative colitis (UC) are currently lacking. The study investigated the therapeutic effects of the folate-chicory acid liposome on both LPS-induced macrophage inflammation models and dextran sulfate sodium (DSS)-induced mouse UC models. MethodsFolate-chicory acid liposome was prepared using the double emulsion ultrasonic method with the aim of targeting folate receptors specifically expressed on macrophages. The study investigated the therapeutic effects of the folate-chicory acid liposome on both LPS-induced macrophage inflammation models and DSS -induced mouse UC models. Furthermore, the effects of the liposomes on macrophage polarization and their underlying mechanisms in UC were explored. ResultsThe average particle size of folate-chicory acid liposome was 120.4 ± 0.46 nm, with an encapsulation efficiency of 77.32 ± 3.19 %. The folate-chicory acid liposome could alleviate macrophage apoptosis induced by LPS, decrease the expression of inflammatory factors in macrophages, enhance the expression of anti-inflammatory factors, inhibit macrophage polarization towards the M1 phenotype, and mitigate cellular inflammation in vetro. In vivo test, folate-chicory acid liposome could attenuate clinical symptoms, increased colon length, reduced DAI scores, CMDI scores, and alleviated the severity of colonic histopathological damage in UC mice. Furthermore, it inhibited the polarization of macrophages towards the M1 phenotype in the colon and downregulated the TLR4/NF-κB signaling pathway, thereby ameliorating UC in mice. ConclusionFolate-chicory acid liposome exhibited a uniform particle size distribution and high encapsulation efficiency. It effectively treated UC mice by inhibiting the polarization of macrophages towards the M1 phenotype in the colon and downregulating the TLR4/NF-κB signaling pathway.